EVALUATION OF CYTOTOXIC EFFECT AGAINST TUMOUR CELLS OF THE ACIDIC POLYSACCHARIDES OF THE FUNGUS Nothophellinus andinopatagonicus

Fungal polysaccharides possess an important bioactive potential, including antioxidant and anticarcinogenic activity. The aim of this work was to determine the activity cytotoxicity against tumour non-tumour cell lines acidic (NAAPs) fungus Nothophellinus andinopatagonicus . effect NAAPs on cells evaluated by MTT assay flow cytometry. analyses determined that glucose most abundant monomer IR spectrum showed typical peaks β-glucans in NAAPs. viability assays revealed significant HL-60, HCT-116 MCF-7 (IC50 = 767,16 μg mL-1, 1256 mL-1 4241,7 respectively); but a much lower line HGF-1 (outside range highest concentration tested (>10 mg mL-1)). affected cycle HL-60 cells, increasing percentage sub G1 phase reducing it S/G2/M phases. Moreover, low concentrations also effective cytotoxic while unaffected, maintaining close 100%. 6.24% 4.63%, for DPPH ABTS method, respectively.